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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4B
All Species:
24.55
Human Site:
S623
Identified Species:
45
UniProt:
Q13523
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13523
NP_003904.3
1007
116973
S623
V
E
Q
N
N
G
S
S
Q
K
K
L
L
A
P
Chimpanzee
Pan troglodytes
XP_518214
1087
126250
S703
V
E
Q
N
N
G
S
S
Q
K
K
L
L
A
P
Rhesus Macaque
Macaca mulatta
XP_001094163
1007
116833
S623
V
E
Q
N
N
G
S
S
Q
K
K
L
L
A
P
Dog
Lupus familis
XP_848551
1042
120804
S658
V
E
Q
N
N
G
S
S
Q
K
K
L
L
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61136
1007
116929
S623
V
E
Q
N
N
G
S
S
Q
K
K
I
L
A
P
Rat
Rattus norvegicus
Q5RKH1
1007
116988
S623
V
E
Q
N
N
G
S
S
Q
K
K
L
L
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508424
1011
117270
A627
V
E
Q
N
N
G
S
A
Q
K
K
L
L
A
P
Chicken
Gallus gallus
XP_001232309
1005
116507
A621
V
E
Q
N
N
G
S
A
Q
K
K
L
L
A
P
Frog
Xenopus laevis
NP_001088314
991
115012
M607
T
E
Q
N
N
G
A
M
Q
K
K
L
L
A
P
Zebra Danio
Brachydanio rerio
NP_998614
1010
116034
P627
Q
E
K
E
G
N
N
P
K
K
P
S
A
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_612010
907
104024
T593
R
Y
L
V
N
G
Y
T
G
Q
G
V
F
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_492008
775
90931
E499
M
Y
K
T
G
L
R
E
L
E
V
L
R
K
L
Sea Urchin
Strong. purpuratus
XP_791787
924
105587
E577
G
I
G
Q
M
G
P
E
N
P
S
L
T
D
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
99
95.3
N.A.
95.1
95.4
N.A.
93
89.7
80.6
68.8
N.A.
41.4
N.A.
36.8
48.3
Protein Similarity:
100
92.6
99.3
96.1
N.A.
97.5
97.8
N.A.
96.5
94
89.4
78.4
N.A.
57.4
N.A.
51.9
59.9
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
93.3
93.3
80
13.3
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
86.6
33.3
N.A.
40
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
16
0
0
0
0
8
70
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% D
% Glu:
0
77
0
8
0
0
0
16
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
8
0
8
0
16
85
0
0
8
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
16
0
0
0
0
0
8
77
70
0
0
8
0
% K
% Leu:
0
0
8
0
0
8
0
0
8
0
0
77
70
0
8
% L
% Met:
8
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
70
77
8
8
0
8
0
0
0
0
0
16
% N
% Pro:
0
0
0
0
0
0
8
8
0
8
8
0
0
8
70
% P
% Gln:
8
0
70
8
0
0
0
0
70
8
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
62
47
0
0
8
8
0
8
0
% S
% Thr:
8
0
0
8
0
0
0
8
0
0
0
0
8
0
0
% T
% Val:
62
0
0
8
0
0
0
0
0
0
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _